The minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with potent agonist opioids. Follow patients for signs and symptoms of respiratory depression and sedation. Other. Pain at injection site; local tissue irritation and induration following subcutaneous injection, particularly when repeated; antidiuretic effect. Swallow Detrol LA extended-release capsules whole. Do not break, crush, or chew before swallowing. generic letrozole order pharmacy uk
Opioids cross the placenta and may produce respiratory depression and psycho-physiologic effects in neonates. An opioid antagonist, such as naloxone, must be available for reversal of opioid-induced respiratory depression in the neonate. Demerol Injection is not recommended for use in pregnant women during or immediately prior to labor, when other analgesic techniques are more appropriate. Opioid analgesics, including Demerol Injection, can prolong labor through actions which temporarily reduce the strength, duration, and frequency of uterine contractions. However, this effect is not consistent and may be offset by an increased rate of cervical dilation, which tends to shorten labor. Monitor neonates exposed to opioid analgesics during labor for signs of excess sedation and respiratory depression.
HCl, and it has the following chemical structure. While many dieters swear by high-, eating large amounts of can also cause a stone to form. If you do not take the same dose each day or if you take this medication every other day, ask your doctor or what you should do if you miss a dose. Woosley RL, Romero KA. www. Chronic use of opioids may influence the hypothalamic-pituitary-gonadal axis, leading to androgen deficiency that may manifest as low libido, impotence, erectile dysfunction, amenorrhea, or infertility.
While serious, life-threatening, or fatal respiratory depression can occur at any time during the use of Demerol Injection, the risk is greatest during the initiation of therapy or following a dosage increase. Monitor patients closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy with and following dosage increases of Demerol Injection. Take this by with or without food as directed by your doctor, usually once or twice daily. This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest.
To prevent needle-stick injuries, needles should not be recapped, purposely bent, or broken by hand. The meperidine in Demerol Injection may increase the frequency of seizures in patients with seizure disorders, and may increase the risk of seizures occurring in other clinical settings associated with seizures. Monitor patients with a history of seizure disorders for worsened seizure control during Demerol Injection therapy. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Tolterodine may cause a condition that affects the heart rhythm QT prolongation. If any of these effects persist or worsen, notify your doctor or promptly. It decreases your 's response to various diseases to reduce symptoms such as swelling, pain, and allergic-type reactions.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. What is the most important information I should know about tolterodine Detrol LA? Because of these risks, reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Drug addiction is a cluster of behavioral, cognitive, and physiological phenomena that develop after repeated substance use and includes a strong desire to take the drug, difficulties in controlling its use, persisting in its use despite harmful consequences, a higher priority given to drug use than to other activities and obligations, increased tolerance, and sometimes a physical withdrawal. This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Read the Patient Information Leaflet if available from your pharmacist before you start using tolterodine and each time you get a refill. If you have any questions, ask your doctor or pharmacist. In clinical studies reported in the literature, changes in several pharmacokinetic parameters with increasing age have been observed. The initial volume of distribution and steady-state volume of distribution may be higher in elderly patients than in younger patients. The free fraction of meperidine in plasma may be higher in patients over 45 years of age than in younger patients. Adrenal insufficiency: Cases of adrenal insufficiency have been reported with opioid use, more often following greater than one month of use. tamsulosin
If necessary, meperidine may be given intravenously, but the injection should be given very slowly, preferably in the form of a diluted solution. Rapid intravenous injection of narcotic analgesics, including meperidine, increases the incidence of adverse reactions; severe respiratory depression, apnea, hypotension, peripheral circulatory collapse, and cardiac arrest have occurred. Meperidine should not be administered intravenously unless a narcotic antagonist and the facilities for assisted or controlled respiration are immediately available. When meperidine is given parenterally, especially intravenously, the patient should be lying down. Tolterodine may also be used for purposes not listed in this medication guide. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Cases of adrenal insufficiency have been reported with opioid use, more often following greater than one month of use. Presentation of adrenal insufficiency may include non-specific symptoms and signs including nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood pressure. If adrenal insufficiency is suspected, confirm the diagnosis with diagnostic testing as soon as possible. If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. Wean the patient off of the opioid to allow adrenal function to recover and continue corticosteroid treatment until adrenal function recovers. Other opioids may be tried as some cases reported use of a different opioid without recurrence of adrenal insufficiency. The information available does not identify any particular opioids as being more likely to be associated with adrenal insufficiency. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution is not decomposed by a short period of boiling. Intravenous hydrocortisone or prednisolone have been used to treat severe reactions, with the addition of intravenous chlorpromazine in those cases exhibiting hypertension and hyperpyrexia. The usefulness and safety of narcotic antagonists in the treatment of these reactions is unknown. Your condition will not improve any faster, and your risk of side effects will increase. These are the most common ones. If any of these effects persists or worsens, tell your doctor or promptly. What is tolterodine Detrol LA? Once you have passed the stone, the doctor will have it analyzed to figure out what it was made of. You also might need to collect your pee for 24 hours to have it tested. Do NOT change your dose of Detrol LA extended-release capsules without checking with your doctor. canada evista benefits evista
Drink plenty of water: You should drink at least 64 ounces of water each day. Some of that liquid can be orange juice, lemonade, or limeade. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. What is the most important information I should know about tolterodine Detrol? Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of Demerol Injection with serotonergic drugs. This list is not complete and there are many other drugs that can interact with tolterodine. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Serious, life-threatening, or fatal respiratory depression has been reported with the use of opioids, even when used as recommended. Respiratory depression, if not immediately recognized and treated, may lead to respiratory arrest and death. Opioids have been shown to have a variety of effects on components of the immune system in in vitro and animal models. The clinical significance of these findings is unknown. Overall, the effects of opioids appear to be modestly immunosuppressive. In severe overdose, particularly by the intravenous route, apnea, circulatory collapse, cardiac arrest, and death may occur. enalapril michigan
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Limit dosage and duration to the minimum required. Carpuject are packaged in a Slim-Pak tamper detection package. Note that a needle is not included. Prolonged use of Demerol Injection during pregnancy can result in withdrawal in the neonate. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. Observe newborns for signs of neonatal opioid withdrawal syndrome and manage accordingly. The treatment takes about an hour, and you can usually go home about an hour later.
Chronic use of opioids may cause reduced fertility in females and males of reproductive potential. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Marked mydriasis rather than miosis may be seen due to hypoxia in overdose situations. Meperidine causes a reduction in motility associated with an increase in smooth muscle tone in the antrum of the stomach duodenum. Digestion of food in the small intestine is delayed and propulsive contractions are decreased. Propulsive peristaltic waves in the colon are decreased, while tone may be increased to the point of spasm, resulting in constipation. Other opioid-induced effects may include a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase. The concomitant use of Demerol Injection with all cytochrome P450 3A4 inhibitors may result in an increase in meperidine plasma concentrations, which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression. In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in meperidine plasma concentration. Use Detrol LA extended-release capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions. Hold the squeeze for 10 seconds, then rest for 10 seconds. Surgery: Another way doctors can get rid of a kidney stone is to cut a small hole in your back and through your kidney in order to remove the stone. If this procedure is done, you could have to stay in the hospital for several days. It may rarely harm an unborn baby. Discuss the risks and benefits with your doctor. Infants born to mothers who have been using this medication for a long time may have problems. This medication may lower your ability to fight infections. This may make you more likely to get a serious rarely fatal infection or make any infection you have worse. Check the Rx Outreach website for the exact price and most current medication list. For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products. The following adverse reactions associated with the use of meperidine were identified in clinical studies or postmarketing reports. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Inadvertent injection about a nerve trunk may result in sensory-motor paralysis which is usually, though not always, transitory. Assess each patient's risk for opioid addiction, abuse, or misuse prior to prescribing Demerol Injection, and monitor all patients receiving Demerol Injection for the development of these behaviors and conditions. generic disulfiram now available
What happens if I miss a dose Detrol LA? Oxybutynin belongs to a class of drugs known as antispasmodics. All medicines may cause side effects, but many people have no, or minor, side effects. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. Meperidine and normeperidine are excreted by kidneys. Individually titrate Demerol Injection to a dose that provides adequate analgesia and minimizes adverse reactions. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. If there's a blockage, you may need surgery. Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines such as cetirizine, diphenhydramine drugs for sleep or anxiety such as alprazolam, diazepam, zolpidem muscle relaxants, and narcotic pain relievers such as codeine. isfe.info midamor
Older adults may be more sensitive to the side effects of this drug, especially QT prolongation see above drowsiness, confusion, constipation, or trouble urinating. Drowsiness and confusion can increase the risk of falling. This information should not be used to decide whether or not to take Detrol LA extended-release capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Detrol LA extended-release capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Detrol LA extended-release capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Detrol LA extended-release capsules. Side Effects List Detrol LA side effects by likelihood and severity. How does your doctor know if you really do have a kidney stone? Demerol Injection may cause severe hypotension including orthostatic hypotension and syncope in ambulatory patients. Symptoms can vary and can range in severity. dilantin
QTdrugs List, AZCERT, Inc. Pfizer also has programs that provide eligible patients with insurance, support assistance, and medicines at a savings. Contact Pfizer RxPathways for details 844-989-7284. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately. Demerol Injection, like other opioids, can be diverted for non-medical use into illicit channels of distribution. Careful record-keeping of prescribing information, including quantity, frequency, and renewal requests, as required by state and federal law, is strongly advised. For certain products of this drug, an empty tablet shell may appear in your stool. This is harmless. The stones can be brown or yellow, and smooth or rough. Moderate. These medicines may cause some risk when taken together. If you are taking this once daily and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. But they are created when your has high levels of certain minerals.
Store at room temperature away from moisture and heat. Pfizer also has programs that provide eligible patients with insurance support, copay assistance, and medicines for free. Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Demerol Injection should be used with caution in patients with atrial flutter and other supraventricular tachycardias because of a possible vagolytic action which may produce a significant increase in the ventricular response rate. Kathleen Zelman, MPH, RD, Director of Nutrition, WebMD. Medications, electrical stimulation, or surgery. Doctors sometimes prescribe medicines that block the of an overactive bladder. Electrical stimulation of the bladder nerves helps in some cases. Surgery is reserved for severe cases. It aims to increase the amount of urine your bladder can store. If a CYP3A4 or CYP2B6 inhibitor is discontinued, consider increasing the Demerol Injection dosage until stable drug effects are achieved. The concomitant use of acyclovir may increase the plasma concentrations of meperidine and its metabolite, normeperidine. Demerol Injection is achieved. Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in DEMEROL-Injection treated patients may increase meperidine plasma concentrations and prolong opioid adverse reactions. Cordarone, Pacerone dofetilide Tikosyn disopyramide Norpace procainamide Procan, Pronestyl quinidine Quin-G or sotalol Betapace. With this type, urine leaks due to weakened pelvic floor muscles and tissues. PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Detrol LA extended-release capsules while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Detrol LA extended-release capsules. order generic theophylline shop australia
Store Detrol LA extended-release capsules at room temperature, between 68 and 77 degrees F 20 and 25 degrees C. Brief storage at temperatures between 59 and 86 degrees F 15 and 30 degrees C is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Detrol LA extended-release capsules out of the reach of children and away from pets. To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated while using this drug, consult your pharmacist for help in selecting a laxative such as a stimulant-type with stool softener. The opioid antagonists, naloxone or nalmefene, are specific antidotes to respiratory depression resulting from opioid overdose. For clinically significant respiratory or circulatory depression secondary to meperidine overdose, administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant respiratory or circulatory depression secondary to meperidine overdose. First, she will get a medical history and examine you. The findings cannot be clearly attributed to maternal toxicity. Ask your pharmacist about the safe use of those products. If you have any questions about Detrol LA extended-release capsules, please talk with your doctor, pharmacist, or other health care provider. purchase indinavir tablet
The dose should be titrated to the needs of the patient and will depend on the premedication and type of anesthesia being employed, the characteristics of the particular patient, and the nature and duration of the operative procedure. Elderly patients should usually be given meperidine at the lower end of the dose range and observed closely. Demerol Injection may reduce respiratory drive, and the resultant CO 2 retention can further increase intracranial pressure. Monitor such patients for signs of sedation and respiratory depression, particularly when initiating therapy with Demerol Injection. The onset of symptoms generally occurs within several hours to a few days of concomitant use, but may occur later than that. Discontinue Demerol Injection if serotonin syndrome is suspected. Mental or physical problems such as or prevent you from getting to the bathroom in time. Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed Demerol Injection. Addiction can occur at recommended dosages and if the drug is misused or abused. Demerol Injection contains meperidine, a Schedule II controlled substance. This medication is not recommended for use in children younger than 1 year due to increased risk of side effects. Do 3 or 4 sets daily. Meperidine may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression. Parenteral drug products should be inspected visually for particulate and discoloration prior to administration whenever solution and container permit. maxalt
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Tolterodine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. If concomitant use of acyclovir and Demerol Injection is necessary, monitor patients for respiratory depression and sedation at frequent intervals. If you get a kidney stone, you are in danger of getting more later in life. Adverse outcomes in pregnancy can occur regardless of the health of the mother or the use of medications. Even if you have a kidney stone, you may not have any symptoms -- that is, until the stone goes on the move.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. This is a long-acting form of that is used to treat and urinary conditions. Your doctor may want you to save the stone so it can be tested. If she can figure out what kind of stone it is, that may help prevent you from having another one. Americans, most of them women. There are several different types, causes, and treatments.
Other medications can affect the removal of from your body, which may affect how methylprednisolone works. What Are Warnings and Precautions for Tolterodine? Alternatively, consider the use of non-opioid analgesics in these patients.
All of these results will help the doctor figure out how best to treat you. Avoid contact with people who have recently received live such as inhaled through the nose. Meperidine causes miosis, even in total darkness.